Benson T. Akingbemi

Benson T. Akingbemi, D.V.M and Ph.D., is an assistant professor at Auburn University. He is a reproductive biologist who mainly studies male reproduction. His research focuses on how environmental chemicals (synthetic estrogens, phytoestrogens and phthalates) regulate steroid hormone receptors, androgen hormone synthesis and sperm production, which can affect reproductive health.

The concept that ‘androgen is male and estrogen is female’ is no longer tenable because estrogen receptors (ERα and ERβ) are localized, along with androgen receptors, to male reproductive tissues, including testicular Leydig cells.  Data from transgenic mice lacking one or both ER subtypes support the hypothesis that estrogen has a regulatory role in male reproduction.  Importantly, there is growing public concern that chemicals in the environment (food, air, water) may have adverse effects on reproductive health.  These compounds alter the endocrine profile by acting through steroid hormone receptors and are designated endocrine disruptors.  Studies to investigate the role of estrogen, the ER, and the effects of endocrine disruptors on Leydig cell differentiated function and male reproduction are warranted.